The so-called 13-valent vaccine generally refers to the pneumonia 13-valent vaccine, which are inactivated bacteria, and are injected in order to induce the emergence of immunity in the human body, these vaccines are inactivated and generally non-pathogenic. However, in cases where the body’s resistance is weak, it is also easy to induce infection with fever, which is also relatively common. If there is an increase in blood count and C-reactive protein, it means that the fever is caused by an infection and needs to be treated with intravenous antibiotics, such as ceftriaxone or cefoperazone. In addition, for the symptoms of fever, as long as the body temperature is relatively high, more than 38.5 degrees need to use antipyretic treatment. In the case of adults, fever suppositories or indomethacin suppositories can be used to reduce fever by inserting them into the anus. If it is a child, it is recommended to take oral ibuprofen suspension.