Vitiligo is an acquired, idiopathic disease characterized by limited depigmentation and loss of functioning melanocytes in the lesions. The pathogenesis of the disease is still unclear. It is usually believed that the disease is associated with trauma, sun exposure, disease, and mental trauma. The main treatment methods are narrow-wave UVB therapy, psoralen plus phototherapy, glucocorticoid therapy, immunosuppressive therapy and surgical epidermal graft aspiration therapy. However, many patients are unable to receive the above treatments due to their conditions. I have treated a large number of vitiligo patients in decades of clinical work and have achieved good results. The treatment methods are as follows: Wang Qi, Department of Dermatology, First Affiliated Hospital of Baotou Medical College 1. oral compound glycyrrhizin tablets and transfer factor oral solution. 2. Apply tincture of bone marrow externally on the white spots and puncture with plum blossom needle. Apply it externally while puncturing. No time limit, no time limit, you can do it when you have time. Tincture of bone marrow can be prepared by yourself, with 1 or two of bone marrow soaked into 200 ml of 75% alcohol in a glass container, soaked for about 10 days, the liquid becomes brownish red can be used. Use a few times will appear white class skin redness, swelling, itching, serious cases can also blister. All the above are normal phenomena. 3, redness, swelling, blistering immediately stop the use of tincture of bone marrow, stop the use of plum blossom needle puncture, can be applied externally fluticasone propionate and furnace glycolic lotion. 4. Continue to do step 2 repeatedly after the redness, swelling, itching and blistering subsides. This is repeated medication, irritation, redness, swelling, receding, then redness, swelling and receding. After several iterations, small black dots will appear in the white spots, or what we call skin islands. The skin island gradually expands, fuses, and connects into one, and the vitiligo is cured. If you have the condition, you can combine it with narrow wave violet light irradiation and topical application of tacrolimus ointment. The above methods vary from person to person, but as long as you adhere to the treatment will have a very good treatment effect, many patients are also cured as a result. The actual fact is that you can find a lot of people who are not able to get a good deal on this. It is necessary to progress step by step. The actual tincture of bone marrow is irritating, the size of the reflection also varies from person to person, when you start using a small amount of topical application, so as not to react too much, blisters, vesicles secondary infection. If the hundred area is relatively large you can repeatedly use the drug in the center of the white spot and perform puncturing to make the early appearance of the skin island.