Although there are many vitiligo treatment methods, there is no one treatment method that is a special treatment and suitable for all patients. The treatment of vitiligo must be individualized according to each individual patient. In most cases, combined treatment is required. The common methods of vitiligo non-surgical treatment are as follows: 1, whole body phototherapy: using narrow spectrum UVB, early application efficiency up to 70%. Treatment 2-3 times a week (every other day or once every two days), only local itching and dry skin adverse reactions, suitable for pregnant and lactating women and children. It is one of the preferred treatments for generalized vitiligo. Combined with vitamin E oral, can improve the efficacy. 2, laser treatment: 308 excimer laser is suitable for limited (less than 30% body surface area), stable vitiligo. It can be used twice a week for 24-48 times of treatment. The combination of tacrolimus can improve the efficacy. It can also be combined with short-term oral glucocorticoids. 3, glucocorticoid treatment: topical glucocorticoids are preferred. Small doses of intermittent oral glucocorticosteroids can also be used. 4, topical tacrolimus ointment, pimecrolimus cream: suitable for head, face and mucous membrane vitiligo. 5, topical vitamin D derivatives: topical carbotriol or tacalcitol.