The most common causes of painful urination are urinary stones, prostate enlargement, prostate cancer, prostatitis, urethritis, etc. Depending on age, drinking habits, and whether or not fever is present, the first diseases considered are different. Once the painful urination occurs, it is first recommended that the patient seek medical attention in time to improve routine urine and urinary ultrasound and other routine examinations, and treat the disease according to its cause. Urinary stones occur in various populations. In patients with urinary stones, painful urination is often accompanied by lumbago, which is a radiating pain caused by stone impaction, and the symptoms are usually relieved after the stones are treated. Prostate enlargement is mostly seen in older men and is caused by bladder irritation due to bladder outlet obstruction. Early on, it can be treated by using prostate enlargement medications such as finasteride + tamsulosin. In severe cases, if urinary retention occurs, you can consider treatment by transurethral electrodesiccation of the prostate. Older men should also be alert to the presence of prostate cancer when they experience painful urination. The painful urination caused by prostate cancer is often easily overlooked by prostate enlargement. Screening PSA is the key, prostatitis and urethritis often appear in young and middle-aged men, and timely urinary routine and urinary ultrasound are the main ways to determine this. Drinking plenty of water, reducing sitting and timely medication is important. To sum up, once the male urinary pain occurs, seek medical attention in a timely manner, only with a clear diagnosis can the right treatment be given, otherwise the condition may be delayed.