Currently, people are afraid of talking about “cancer”, especially for pancreatic cancer with higher malignancy, which is known as the “king of cancer” due to the lack of effective treatment, unsatisfactory long-term outcome after surgery, early metastasis, poor prognosis and high mortality. In the past decades, with the development of medical treatment, the diagnosis and treatment of pancreatic cancer has made some progress, especially the detection rate of early stage pancreatic cancer has increased greatly, and the prognosis of this group of patients has improved significantly. Therefore, we need to re-understand this disease and stop fearing pancreatic cancer, instead, we should understand it from a scientific perspective and pay attention to it. Early stage pancreatic cancer lacks specific symptoms and signs. Its clinical manifestations depend on the location of the tumor, early or late stage of the disease, the presence or absence of metastasis and the invasion of adjacent organs. The most common early manifestations are upper abdominal fullness and discomfort and epigastric pain, which may be accompanied by loss of appetite, lethargy and weakness. If the above symptoms are newly appeared in middle-aged people over 40 years old, they should be alert to the possibility of pancreatic cancer, in addition to considering common diseases of liver and gallbladder, gastrointestinal tract, etc. At present, there is no specific preventive measure for pancreatic cancer, but only prevention against possible causes and risk factors, as well as attention to improve the health quality of the body. The occurrence of pancreatic cancer is closely related to poor lifestyle and unreasonable nutrition such as smoking, excessive intake of fat and protein in the diet and alcohol abuse. Therefore, in order to avoid or reduce the occurrence of pancreatic cancer, we should quit drinking and smoking, and advocate a low-fat, low-protein, high-fiber and high-vitamin diet, i.e., eating more fresh fruits and vegetables, etc. In addition to the above mentioned primary prevention measures against the causes of pancreatic cancer, early detection, early diagnosis and treatment of pancreatic cancer, i.e. secondary prevention, are of more practical significance. Based on the characteristics of pancreatic cancer, people over 40 years old who have unprovoked upper abdominal pain, fullness and distension, loss of appetite, weight loss, weakness, diarrhea, back pain, recurrent pancreatitis, sudden onset of diabetes or sudden aggravation of existing diabetes should be considered as high-risk group for pancreatic cancer and should be alerted to the possibility of pancreatic cancer and should seek medical attention and regular medical checkup. Pancreatic cancer is a highly malignant tumor with a very poor prognosis. The survival period of untreated pancreatic cancer patients is about 4-6 months, that of patients treated with palliative surgery is about 7-9 months, and that of patients after radical resection is generally about 16 months. Early diagnosis and early treatment is the key to improve the prognosis of pancreatic cancer, and some data show that early radical resection of the tumor can lead to a 5-year survival rate of 20%-40%, and the survival rate increases slightly after combined radiotherapy and chemotherapy. Thus, as long as we pay enough attention to pancreatic cancer and achieve early detection, early diagnosis and early treatment, the so-called “king of cancers” is not invincible.