Helicobacter pylori is mainly transmitted through fecal-oral transmission, where the bacteria are excreted through feces, colonize in water, and then ingested by the body. It can also be spread by mouth-to-mouth transmission, bacteria colonized in oral saliva, through kissing, mouth-to-mouth feeding transmission, after understanding the transmission route can be taken to prevent the following ways: 1, to develop good hygiene habits, to do before and after meals, diligent hand washing, avoid drinking raw water, raw fruits and vegetables to wash clean; 2, pay attention to oral hygiene, advocate after meals rinse mouth, regular replacement of toothbrushes, disinfection of cups; 3, Chinese people used to Collective dining, collective dining is best to use the meal sharing system, the public chopsticks system, pay attention to dish sterilization, and stop parents from chewing food and giving it to their children for mouth-to-mouth feeding.