I. Overview: IgA nephropathy is a primary glomerulopathy in which IgA or IgA deposits are predominant in the glomerular thylakoid region. IgA nephropathy is the most common cause of glomerulogenic hematuria. Symptoms: Prevalent in adolescents, more common in males. The onset of the disease is usually preceded by an infection, often an upper respiratory tract infection (24-72 hours, occasionally shorter) with sudden onset of granulomatous hematuria lasting from a few hours to several days. The onset of brucellar hematuria may be accompanied by mild systemic symptoms such as low-grade fever, low back pain, and general malaise, with painful urination sometimes being prominent. IgA nephropathy is the most common pathological type of primary glomerulopathy presenting with simple hematuria, accounting for about 60%-70% of patients. 10-15% of patients present with acute nephritis antibody syndrome such as hematuria, proteinuria, hypertension, decreased urine output, and mild swelling. A small number of patients with IgA nephropathy (<10%) can be combined with acute renal failure (ARF), most of them with episodes of carnitic hematuria, often with severe back pain, renal biopsy can show acute tubular necrosis, extensive erythrocyte tubular pattern and partial formation of small crescent (50% of glomeruli), ARF in the above patients is mostly reversible; a few patients can present with malignant hypertension, and those with persistent hypertension have a poor prognosis. Hypertension is uncommon in the early stage of IgA nephropathy (<5%-10%), but increases with the disease duration, and the incidence of hypertension is 30%-40% in patients with IgA nephropathy aged over 40 years. A small number of patients may present with malignant hypertension, and those with persistent hypertension have a poor prognosis. Within 10 years, 10-20% of patients with IgA nephropathy develop chronic regional renal failure (CRF), and it can be roughly estimated that 1-2% of patients develop CRF each year after the Japanese diagnosis of IgA nephropathy is established. Laboratory tests: Urine sediment examination often shows increased urinary red blood cells, and phase contrast microscopy shows predominantly deformed red blood cells, suggesting glomerulogenic hematuria, but sometimes mixed hematuria can be seen. Urine protein can be negative, but a few patients showed massive proteinuria (>3.5g/d). Chinese repeatedly check blood IgA, elevated up to 30%-50%. Fourth, the department diagnosis: IGA nephropathy involved in the diagnosis relies on the immune excellent pathological examination of kidney biopsy specimens, that is, the glomerular membrane area or accompanied by capillary walls with IgA-based Hangzhou immunoglobulin in granular or mass-like deposits. When diagnosing talent primary IgA nephropathy, the core can be established only after excluding cirrhosis of the liver, allergic purpura and other disease meetings caused by secondary IgA deposition. V. Dr. treatment and prognosis: IgA nephropathy is a primary glomerulopathy in which the renal immune focus pathology will be the same, but the special clinical manifestations, pathological changes and prognosis are very variable, and its treatment attainment should be based on the promotion of different items of clinical and pathological comprehensive insist on giving reasonable treatment internal medicine. 1, simple hematuria or (and) mild proteinuria (