Hepatitis B self-healing, broadly speaking, refers to the positive to negative hepatitis B virus, the general positive to negative hepatitis B indicators are: 1, serum hepatitis B virus surface antigen; 2, hepatitis B virus DNA; 3, hepatitis B virus e antigen. When 2 and 3 negative, accompanied by 1 turn negative, it indicates that hepatitis B is cured. An occasional turn negative is not a true self-cure. A true self-cure turn negative is one in which at least three consecutive tests are negative, each at an interval of 1 month, lasting for 6-12 months and still negative. Not all hepatitis B patients can have the ability to heal themselves, which is related to the age of infection and the body’s immune function of the hepatitis B virus patient. When the hepatitis B virus first enters the body, the onset of disease depends on the number of hepatitis B viruses, how actively the virus is replicating, and the body’s immune system. We call the number of hepatitis B viruses and the degree of their activity the intensity of infection, and the disease develops when the intensity of infection is greater than the body’s immune capacity. If the immune function is developed and the body’s cellular and humoral immunity is capable of immune attack against the hepatitis B virus and clear the virus, then the disease can be naturally converted. There is also the application of antiviral drugs to turn negative. Therefore, reducing the intensity of infection, increasing the ability of the immune system, and applying antiviral drugs if necessary are the precursors to self-healing. As for the perception of self-healing of hepatitis B, we hope that many hepatitis B patients will not blindly pursue the full conversion of hepatitis B test indicators, as long as they receive regular, systematic and individualized treatment, most patients can obtain satisfactory treatment results.