The level of elevated bilirubin in patients with pancreatic cancer is usually difficult to determine, and it is related to the location of the lesion, the level of obstruction, etc. If it does not cause bile duct obstruction, there may be no elevated bilirubin. Pancreatic cancer is a kind of malignant tumor of digestive tract with insidious onset, rapid progression, and extremely poor therapeutic effect and prognosis. Depending on the location and size of the tumor, organs involved and its severity, pancreatic cancer patients may present with epigastric or back pain, nausea, abdominal distension, jaundice, new-onset diabetes mellitus, weight loss, and changes in stool characteristics, etc. Occasionally, acute pancreatitis is seen as the main manifestation of the patient. The common bile duct and the pancreatic duct usually have a “common channel”, so if the pancreatic tumor invades or compresses the pancreaticobiliary duct, it can lead to cholestatic jaundice. The level of jaundice is usually twice as high as the normal level, but there are individual differences and it is not necessarily higher in all patients. If the tumor does not invade or compress the bile ducts, the patient’s bilirubin level may be normal. If pancreatic cancer is suspected or diagnosed, it is recommended to go to a regular hospital for a comprehensive assessment of the condition and follow the doctor’s instructions for treatment to avoid delays.