Zou, a female, was 2 months old at the time of presentation. The child was found to have jaundice 2 months after birth and was examined at Hunan Children’s Hospital. There was a history of jaundice at birth, which subsided after blue light irradiation. Physical examination revealed moderate jaundice of the skin and sclera, 2.5 cm below the rib cage of the liver with soft texture and 1.0 cm below the rib cage of the spleen. laboratory tests revealed abnormal liver function (elevated total bilirubin, elevated direct and indirect bilirubin, glutaminase and glutamic oxalacetic transaminase), positive CMV-IgM, positive CMV-IgG, and blood CMV-DNA 4.6*04 copies/ml. Fundus examination Normal, cranial CT examination was normal, and brainstem hearing evoked potentials showed bilateral hearing impairment. The diagnosis was congenital cytomegalovirus disease (hearing impairment with hepatitis). He was given ganciclovir (intravenous, Q12h,) antiviral, hepatic protection with dichloroacetate, biliary stimulation with ursodeoxycholic acid, murine nerve growth factor and splenaminic peptide, etc. On review 2 weeks later, jaundice was significantly reduced, the liver was 1.5 cm below the rib cage, the spleen was not reached, liver function showed a significant decrease in bilirubin, but transaminases were still elevated. The blood CMV DNA quantification result showed 2.1*03 copies/ml. The treatment was changed to ganciclovir (QD) and treated with dicyclomine tablets to lower the enzyme for two weeks. The jaundice subsided, the liver was 1 cm below the rib cage, the spleen was not detected, the liver function showed normal transaminases, and the blood CMV DNA was <400 copies/ml. The brainstem hearing evoked potential was normal. Ganciclovir was discontinued, dicyclomine was reduced, and splenamine-based oral therapy was continued. One month later, he was reexamined: no jaundice, 1 cm below the liver ribs, no spleen, normal liver function, CMV DNA quantification <400 copies/ml. The child's growth and development were assessed as normal.