Newborns with positive core antibody to hepatitis B, if the core antibody is found to be positive when the mother-infant blockade has been completed, the general impact is not significant, but if the mother has not been successfully blocked there will be a certain impact, and we need to refer to the hepatitis B penta and other indicators of hepatitis B viral DNA to determine whether or not the newborn has been infected with hepatitis B, and if it is infected, it needs to be promptly treated. 1. Completion of mother-to-child blockade: in the case of maternal infection with hepatitis B virus may directly affect the newborn, the mother’s incomplete hepatitis B virus particles through the umbilical cord blood into the fetus caused by the stimulation of the baby’s immune system to produce surface antibodies and core antibodies, this incomplete hepatitis B virus is not active and infectious, but immunogenic, resulting in the newborn’s hepatitis B core antibody is positive. However, if the mother-to-child blockade has been completed, the newborn’s positive hepatitis B core antibody is only a simple positive indicator, usually has little effect, and the core antibody will disappear after a prolonged period of time. 2. Without PMTCT: If the mother is infected with hepatitis B virus and it is not successfully blocked during pregnancy, it will directly affect the newborn during delivery. Therefore, after the birth of the newborn will be found to be positive for core B antibody, the body has hepatitis B virus, if not treated in time, the impact is relatively large, easy to develop into chronic hepatitis B. At present, it is only found that the newborn’s hepatitis B core antibody is positive, but also combined with the results of hepatitis B 5 other 4 tests, hepatitis B virus DNA for diagnosis and analysis, once the virus is found to exist, it should be treated in time, if you have any questions about the treatment, you need to consult a doctor in a timely manner.