Patients with HFMD have pain, but this pain refers to the sore throat, not the pain of the rash on the hands and feet. The sore throat is caused by the appearance of red papules and herpes on the mucous membrane of the pharynx and the mouth, and after the herpes breaks down, small ulcers will form, and in severe cases, the small ulcers will fuse into large ulcers. The ulcerated surface will feel more painful after being stimulated by saliva or dietary materials, which is called sore throat of HFMD. The sore throat may be severe, and in severe cases, the child may not be able to eat or even drink water, and the only way to supply energy and water is through intravenous fluids. The sore throat of HFMD does not last too long. The symptoms of sore throat may be gradually aggravated during the first three days or the first four days, and then disappear relatively quickly after the fourth day, often within one or two days.