Condyloma acuminatum is one of the common venereal diseases and is mainly transmitted through direct sexual contact. However, a small percentage of patients can be infected indirectly, such as may be related to sanitary utensils or supplies, local use of sexual massage health appliances contaminated by the patient, etc. Warts are caused by human papilloma virus (HPV) infection of the skin mucosa.
Traditional treatment methods include: local cryotherapy; local carbon dioxide laser treatment (or electrocautery, electrocautery treatment); local topical drug treatment; and other adjuvant treatments. Cryotherapy is less expensive ($50-$100) and has a more superficial wound after treatment, which heals quickly and is less prone to scarring, but the recurrence rate is greater than 50%. Carbon dioxide laser treatment is much more expensive than cryotherapy ($100-$1,000) and requires local anesthesia. The recovery of the treated wound is a little slower and sometimes scarring can occur. Although topical topical medication can eliminate the need for a hospital visit, it often causes local redness and swelling due to the method of use or improper selection of medication. The cost is high, and the effectiveness of treatment varies greatly from person to person, and some treatments are controversial.
I. Treatment principle of photodynamic therapy.
After inputting photosensitizer into human body and irradiating the lesion with specific wavelength of light after a certain period of time, through a series of photochemical and photobiological reactions, with the participation of molecular oxygen, monomorphic oxygen and/or free radicals are generated to oxidize and destroy various biological macromolecules in tissues and cells, causing irreversible damage to the abnormal proliferating active cells and finally causing cell death to achieve the therapeutic purpose.
II. Indications for photodynamic therapy.
1.Pre-cancerous skin diseases and skin malignant tumors, such as solar keratosis, basal cell carcinoma, squamous carcinoma.
2.Treatment of non-malignant tumor skin diseases, such as acanthosis, vascular malformation, acne vulgaris.
Three, the steps of photodynamic therapy
1. Fresh medicinal solution will be prepared by the medical staff for use in the treatment.
2, fresh solution wet compress the affected area for 3 hours, and according to the specific circumstances of the corresponding local sealing package.
3, red light irradiation lesion local, irradiation time is usually 20 minutes.
Fourth, the adverse effects of photodynamic therapy
The most common adverse reaction is localized pinprick-like pain when illuminated, which can be tolerated by most patients, or will be relieved later on their own, generally without special treatment. Patients should be instructed not to be overly nervous, and for those with obvious pain, topical application of “compound lidocaine cream” may be used or the doctor should be notified for further special treatment.
V. Treatment cost
1, the cost of drugs: aminoglutaric acid hydrochloride (Ala, ALA) each drug more than 700 yuan.
The general area is not very large condyloma acuminata patients, each treatment using 1. The area is large then increase the dosage.
2.Treatment cost; 300 yuan per time / light spot (Peking University People’s Hospital)
The general local light exposure time is 20 minutes
3, usually treated once a week, about half a day; 3 times for a course of treatment.
VI. Precautions for photodynamic therapy.
1, special parts of the condyloma acuminata (such as warts occurring in the urethra, urethra, vulva around the opening of the glands) can be directly selected photodynamic therapy, good efficacy, less recurrence.
2, after local carbon dioxide laser or freezing treatment, repeated recurrence of patients, it is recommended that local photodynamic therapy 2-3 times.
3, after conventional traditional treatment, you can choose photodynamic therapy for 2-3 times to consolidate treatment and prevent recurrence.
4, for larger warts, it is recommended to use carbon dioxide laser or freezing methods to remove large warts first, then choose photodynamic therapy, which can reduce the cost of treatment, but also shorten the treatment time.
5, please note that any kind of treatment currently can not absolutely prevent the recurrence of condyloma acuminata, general photodynamic therapy 3 times after the wart recurrence rate of less than 10%.