A woman who has a Down’s syndrome screening test in early to mid-pregnancy, which indicates a high risk of trisomy 21, means that she is at high risk of having a Down’s child, but this test is only a screening test and there are false positives and false negatives. For women who are pregnant and want to have children, they usually need to have an ultrasound at 12 weeks of pregnancy to see the growth and development of the fetus, verify the gestational week and measure the thickness of the posterior nuchal translucency layer before having blood drawn for the Down’s screening test. The risk of having a child with Down’s syndrome is accurately calculated through a formula based on the plasma levels of alpha-fetoprotein and free hCG, as well as the age of the mother and the size of the fetus, which are classified as high risk, critical risk and low risk. If the risk is low, it generally means that the chance of having a Down’s child is low. If the risk is high, it means that the chance of having a Down’s child is high and further prenatal diagnosis will be done, i.e. amniocentesis. Therefore, if you have a high risk of trisomy 21, you do not need to induce labor immediately to terminate the pregnancy, because Down’s syndrome screening is not a confirmatory test, but only a screening test, and amniocentesis is needed to further confirm the diagnosis. Non-invasive DNA can be considered for those who have signs of preterm miscarriage or are otherwise unsuitable for amniocentesis, but it is important to fully communicate that non-invasive DNA is only a screening test, not a confirmatory test.