Thermal ablation therapy for thyroid nodules should be performed into a standard operating room! There are many reasons for this, with the reliance on the anesthesiologist’s management of emergencies and resuscitation being a major consideration. The best form of anesthesia for thermal ablation of thyroid and parathyroid nodules is local anesthesia, which requires the local anesthetic lidocaine. People tend to misunderstand local anesthesia, thinking that local anesthesia is simpler and safer, and therefore do not need to “make a big deal”, but do not know that the use of lidocaine is risky, and even fatal. Reportedly, the central nervous system toxicity of lidocaine serious reaction, lidocaine cardiovascular toxicity concentration and central nervous system toxicity concentration has a wide range between the cardiac toxicity occurs after the central nervous system toxicity, therefore should not be ignored. Lidocaine’s systemic adverse reactions can be life-threatening in serious cases, once occurred should be timely rescue, must pay attention to the following points: (1) anaphylactic shock patients must be immediately on-site rescue, after the recovery of the condition and then stay in the observation; (2) for patients with convulsions at the same time appearing low blood pressure and respiratory arrest, any barbiturates should not be applied or used with caution, this kind of patients can be used to Valium; (3) for central nervous system toxicity reaction, the patient appearing Respiratory arrest or respiratory depression should be done to assist breathing, such as respiratory recovery should be done endotracheal intubation, improve ventilation, correct oxygenation; (4) angioedema patients occurring vocal edema, can not be relieved by resuscitation and the emergence of severe asphyxia must be done immediately when tracheotomy.