High preprandial glucose mostly refers to high fasting glucose, with a wide range of drugs, you can consider sulfonylureas, biguanides or thiazolidinediones: 1. Sulfonylureas: divided into one generation, two generations and three generations of drugs, clinically common drugs are gliquidone, gliclazide, glimepiride, etc. You can choose drugs under the guidance of doctors, according to the kidney function, liver function and insulin reserve function of patients; 2. Guanidine drugs: clinically common drugs are metformin and phenylephrine. The effect of hypoglycemia is achieved by reducing the absorption of glucose in the intestine, and the hypoglycemic effect is lower than that of sulfonylureas, but it is not easy to have hypoglycemic reaction. Obese people and patients with ineffective sulfonylureas can choose these drugs, but pay attention to benzylguanidine prone to lactic acidosis, metformin can be preferred for treatment; 3, thiazolidinediones: belong to insulin sensitizers, such as pioglitazone and rosiglitazone. By enhancing the sensitivity of insulin in peripheral tissues and reducing insulin resistance to achieve the effect of sugar reduction, they can be used together with insulin. These drugs are suitable for patients with type 2 diabetes and obesity, and should be avoided for patients with type 1 diabetes, diabetic ketoacidosis, heart failure and severe liver damage. In addition to these commonly used drugs, you can also choose DPP-4 inhibitors, SGLT-2 inhibitors and other drugs to assist in the treatment according to your condition under the guidance of your doctor.