Whether or not a person with hepatitis B virus can become pregnant is largely determined by whether or not the liver itself can withstand the burden of the entire pregnancy and delivery process. Some people want to wait until the infectiousness of hepatitis B virus is reduced to zero or very low level before they get pregnant, which is not very realistic; the other part of people are pregnant with the mentality of trying without considering their body’s ability to bear it, which is dangerous. In order to ensure the safety of mother and child and to minimize the transmission of hepatitis B virus to the next generation, it is necessary to get pregnant under the guidance of a specialist in a regular medical institution in one of the following six cases: 1) acute hepatitis B with significant liver function abnormalities, and it is best to delay pregnancy until the disease is stabilized; 2) hepatitis B virus infection for a long time and serious liver damage, confirmed by liver biopsy The liver is cirrhotic, accompanied by obvious thrombocytopenia, hypersplenism, coagulation dysfunction; 3, chronic hepatitis B patients with more obvious liver function abnormalities, and liver function fluctuations, often accompanied by protein ratio inversion or hypoproteinemia; 4, chronic hepatitis B patients with serious extrahepatic system performance, such as nephropathy, aplastic anemia hepatitis B patients will undergo a series of physiological changes if pregnancy, and Some physiological changes can aggravate the burden of liver disease and further aggravate the original liver damage. For example: (1) the metabolism is high during pregnancy and nutrients are consumed; (2) the metabolism and detoxification of the fetus depends on the maternal liver; (3) a large number of sex hormones, such as estrogen, produced by endocrine changes during pregnancy need to be metabolized and inactivated in the liver; (4) fatigue, bleeding, surgery and anesthesia during childbirth can increase the burden on the liver. (5) Those who have a history of pregnancy but terminate it because the liver cannot tolerate it; (6) Those who are infected with hepatitis B virus and have obstetrical and gynecological problems that make them unfit for pregnancy, such as a history of repeated cesarean deliveries. Pregnancy complications complicate the hepatitis B condition and increase the difficulty of diagnosis and treatment. In the case of concomitant hyperemesis, the pregnant woman’s HBV is usually more severe and highly susceptible to massive hepatic necrosis. The increased burden on the liver during pregnancy makes pregnant women susceptible to viral hepatitis infection or contributes to the worsening of pre-existing liver disease. Hepatitis is more severe in pregnant women than in non-pregnant women, and the later the duration of pregnancy, the more likely it is to develop into severe hepatitis, and pregnant women with hepatitis are particularly susceptible to chronic hepatitis. The death rate of pregnant women with hepatitis is higher than that of non-pregnant women, and especially severe hepatitis is a great threat to mother and child, and in rare cases, liver failure and maternal death may occur.