Hepatitis B Virus Markers (Hepatitis B 5, also known as Hepatitis B 2.5) refer to the following: Surface Antigen (HBsAg) and Surface Antibody (anti-HBs), e Antigen (HBeAg) and e Antibody (anti-HBe), and a single Core Antibody (anti-HBc). What are the meanings of the “Hepatitis B 2.5”? Positive surface antigen (HBsAg): signifies hepatitis B virus infection, which must be present in the body, but does not indicate whether the virus is replicating or not, whether the disease is mild or severe, and whether it is acute or chronic. Surface antibody (anti-HBs) positive: indicates that after infection with hepatitis B virus has produced protective immunity against the virus, and will not be infected with hepatitis B virus again; or after injection of hepatitis B vaccine, the immune response has occurred, and protective antibodies have been produced. Positive e antigen (HBeAg): reflects active replication of hepatitis B virus (HBV), viremia, and highly infectious blood, but does not indicate whether the disease is mild or severe. Positive e-antibody (anti-HBe): the appearance of e-antibody has two very different situations: in the serum aminotransferase continues to be normal, indicating that the hepatitis B virus is low replication or non-replication, in the recovery period of infection; in the serum aminotransferase is elevated or sometimes high and sometimes low, HBV DNA is still increased in the “small triple” chronic hepatitis B, the serum aminotransferase is elevated or sometimes high and sometimes low, HBV DNA is still increased. HBeAg negative and anti-HBe positive because of the occurrence of viral mutation, so “small triple positive” chronic hepatitis patients are prone to relapse after treatment. Positive core antibody (anti-HBc): there are also 2 different cases: positive with HBsAg indicates hepatitis B virus infection; positive with anti-HBs indicates that immunity against hepatitis B virus has been acquired after infection. The most common clinical 135 positive: major triple positive 145 positive: minor triple positive The second positive: indicates that there are protective antibodies and you will not be infected with hepatitis B. The second positive: indicates that there are protective antibodies and you will not be infected with hepatitis B. 245 positive: i.e. three antibody positives, indicating previous infection and spontaneous clearance.