Small blisters on the soles of the feet are considered to be blistering tinea pedis, herpes sweat, palmoplantar pustulosis, etc. The main treatment is medication, and the appropriate medication should be chosen according to the specific cause of the disease. 1. blistering tinea pedis: blistering tinea pedis is a type of tinea pedis, a fungal infection, you can apply antifungal drugs, such as econazole, ketoconazole, naftifine, terbinafine cream and so on. Oral terbinafine and itraconazole can also be taken if the symptoms are severe. 2. Sweat herpes: sweat herpes usually occurs symmetrically on the hands or feet, the main symptom is the appearance of small blisters, the cause of the disease is not particularly clear, if the symptoms are not particularly serious, can be used externally mometasone furoate cream, haldolone, etc., if the itching is serious, you can also take oral loratadine, cetirizine. 3. palmoplantar pustulosis: palmoplantar pustulosis is common in middle-aged and elderly women aged 50-60, the cause of the disease is not particularly clear, mainly manifested in the palms of the hands or soles of the feet aseptic pustules, can be coated with hydrocortisone cream, dexamethasone cream treatment, the symptoms of the more serious can be taken orally Avian A, cyclosporine, methotrexate and so on. Small blisters on the soles of the feet may have other causes, it is recommended to go to the hospital in time to improve the examination to clarify the cause of the disease, under the guidance of the doctor to give targeted treatment or treatment. All the drugs should be used in accordance with the doctor’s instructions, do not self-medication.