Abdominal discomfort About 60% of patients have upper abdominal discomfort in the early stage, which is easily confused with symptoms of gastrointestinal and hepatobiliary diseases. Loss of appetite and emaciation The early symptoms of pancreatic cancer may include loss of appetite and emaciation, with loss of appetite as the first symptom in about 10% of cases and emaciation in some cases. About 40% to 70% of patients with pancreatic cancer have abdominal pain as the most presenting symptom. The causes of abdominal pain include: 1) strong contraction of the pancreaticobiliary duct due to obstruction of its outlet, and abdominal pain is mostly paroxysmal and located in the upper abdomen; 2) visceral neuralgia caused by increased pressure in the bile duct or pancreatic duct, which is manifested as dull pain in the upper abdomen, aggravated one to two hours after meals and reduced after several hours; 3) rich innervation of the pancreas. The nerve fibers mainly come from the celiac plexus, the left and right celiac nerve nodes, and the superior mesenteric plexus, and the nociceptive nerve is located in the sympathetic nerve. If the tumor infiltrates and compresses these nerve fiber plexuses, it can cause low back pain, and the degree is intense, and the patient often takes a sitting position or lies on his back side all night long, which is mostly a late manifestation. Jaundice Painless jaundice is the most prominent symptom of pancreatic head cancer, accounting for about 30%. Because of the biological characteristics of pancreatic cancer with peritubular infiltration, jaundice can appear early, but it is not an early symptom. The color of stool becomes lighter as jaundice deepens and finally becomes clay-colored, and the color of urine becomes more and more thick and soy sauce-colored. The majority of patients have fever of varying degrees during the course of the disease, and intermittent low-grade fever often goes unnoticed. In case of biliary tract infection, chills and high fever may occur. Thrombophlebitis is a special manifestation of pancreatic cancer. About 15%-25% of patients develop thrombophlebitis during the disease, most commonly in the lower limbs. If any of the above symptoms occur, you should pay attention to them actively to prevent delaying the disease, and B-ultrasound, CT, tumor markers, etc. can be examined, and PET-CT can also be examined if necessary.