Azoospermia accounts for about 15-20% of male infertility patients. Generally, no sperms are found in 3 consecutive routine semen examinations, which is called azoospermia. The causes of azoospermia are summarized as follows: The first: testicular spermatogenic disorders: can be caused by the following diseases ① azoospermia ② cryptorchidism ③ congenital varicocele insufficiency ④ testicular inflammation ⑤ testicular tuberculosis ⑥ genital injuries: testicular injuries, spermatic cord torsion ⑦ radiation irradiation ⑧ testicular localized temperature is too high ⑨ consumption of cottonseed oil ⑩ varicose veins of the spermatic cord as well as hypogonadotropic and so on. Jinan Military General Hospital urology Liu Junguo second: vas deferens obstruction: ① congenital bilateral vas deferens deficiency ② reproductive duct injury ③ reproductive duct inflammation: epididymitis, epididymal tuberculosis, prostatitis, seminal vesiculitis, etc. ④ seminal vesicle benign tumor: seminal vesicle cysts and so on. Diagnostic process of azoospermia: In the clinic, the process of routine diagnosis of azoospermia is basically as follows: no sperms are seen in the semen examination, no sperms are seen in the three examinations, and then no sperms are seen in the three examinations of semen centrifugation, in order to make clear the cause of azoospermia, it is necessary to do the following examinations: 1) check the development of the second sexual characteristics, especially the development of testes; 2) do the male hormone six examination diagnosis Testicular function; 3, testicular ultrasound or color ultrasound to diagnose testicular somatic lesions; 4, routine hospitals can also give patients a testicular biopsy in order to provide data to confirm the diagnosis of azoospermia; 5, scrotal exploratory surgery for azoospermia patients to provide treatment options.