Toothache caused by facial swelling may be the emergence of wisdom teeth pericoronitis, acute suppurative periapical inflammation and other diseases, you can use metronidazole, amoxicillin and other drugs under the guidance of the doctor to treat. But should also receive the appropriate oral treatment, and drug treatment with better results. 1. Wisdom tooth pericoronitis, some patients have wisdom tooth pericoronitis due to inflammation around the wisdom tooth, may lead to toothache symptoms, you can use anti-infective drugs, such as metronidazole, amoxicillin, cephalexin and so on. 2. Acute purulent periapical inflammation, some patients with acute purulent periapical inflammation periapical tissue pressure increases, there may be a toothache face swelling symptoms, the general effect of medication is not good, you can carry out endodontic treatment, remove the nerve of the tooth. Toothache caused by swollen face is recommended to seek medical advice as soon as possible, the general effect of medication is not obvious, if you want to treat the root of the need for professional oral treatment. Usually need to keep a light diet, pay attention to oral hygiene.