Enlargement of the heart may be due to hypertension, pulmonary hypertension, dilated myopathy, pericarditis, etc. It is necessary to take nifedipine, levofloxacin and other medications for the cause of the disease. 1. Hypertension: this disease is due to the increase of peripheral vascular resistance, the left ventricle ejection is limited, blood stagnation, long-term effect leads to left ventricular hypertrophy. You can take hydrochlorothiazide, nifedipine, metoprolol, enalapril, irbesartan and other antihypertensive drugs. 2. Pulmonary arterial hypertension: the increase of pulmonary artery pressure leads to the right ventricle ejection limitation, and the right ventricle enlargement occurs after the loss of compensation. You can take furosemide, digoxin, warfarin, iloprost, bosentan and other drugs for treatment. 3. Dilated cardiomyopathy: the cause of this disease is not yet clear, may be related to infection, genetics, metabolic disorders and other factors, cardiomyocyte hypertrophy, degeneration, resulting in heart enlargement. You can take captopril, valsartan, carvedilol, spironolactone, hydralazine, ivabradine and other drugs for treatment. 4. Pericarditis: Infection, autoimmune diseases and other factors lead to pericardial inflammatory exudation, pericardial effusion and cause heart enlargement, you can take aspirin, ibuprofen, prednisone, colchicine, levofloxacin and other drugs to treat. If there is an enlarged heart, it is important to seek medical attention as soon as possible and use medication under the guidance of a physician.