Still having pain in the second week of an ankle bone fracture is usually a normal reaction. If the injury is untreated or caused by improper treatment and inflammation, regular treatment, such as medication or surgery, should be given according to the situation. If there is no fracture or dislocation of the ankle joint, the fracture should be treated conservatively with stable immobilization, such as cast immobilization, brace immobilization, and so on. Pain in the second week of treatment is generally normal, and if improper fixation of the cast or brace causes serious pressure and adhesion of the peripheral tissues, the fixation should be adjusted, and anti-inflammatory and analgesic drugs such as indomethacin should be given if necessary. For patients who have not taken treatment after ankle bone fracture, treatment should be actively carried out. If the ankle joint fracture is dislocated, the first step is to strive for anatomical repositioning, stable fixation, and appropriate joint activities. Those who are unsuccessful in manual repositioning should undergo surgical incision and repositioning as early as possible, with internal fixation by Kirschner’s needle and anti-inflammatory and analgesic medication, such as indomethacin, nimesulide, and so on. If the above symptoms occur, it is recommended to go to the hospital in time for early and regular treatment. All the above medications should be used under the guidance of a doctor or pharmacist, avoid self-medication.