Amniocentesis may irritate the uterus leading to miscarriage, but the probability of this is very low. Amniocentesis utilizes transabdominal amniocentesis, using a puncture needle through the abdominal and uterine walls and into the amniotic cavity. It can be used to extract amniotic fluid in the middle and late stages of pregnancy so as to perform clinical analysis and diagnosis or drug injection therapy. This procedure has been performed for many years and is now a safe procedure, and amniocentesis can detect a variety of diseases including genetic disorders. If the clinician evaluates the need for a test, the benefits outweigh the risks. However, it is important to note that prior to the test, it is contraindicated if there are signs of miscarriage, if the temperature has exceeded 37.5°C on several occasions, if there is impairment of the heart, lungs, or liver or kidneys, or if there is acute inflammatory disease of the reproductive system. The operation is strictly clinical, and the test must be performed in the hospital for observation of any adverse reactions after the puncture. During pregnancy, pay attention to rest more, at the same time should relax, avoid tension, anxiety, any discomfort should be timely to the hospital, the doctor to clarify the diagnosis, and cooperate with the doctor symptomatic treatment.