Swelling of inner calf is mostly caused by muscle damage, lower limb venous return obstacle, renal dysfunction and other factors, and the cause should be identified in time. 1. Muscle damage: due to local impact or improper exercise and other factors, the calf muscle can be caused by damage to the subcutaneous capillary rupture can lead to swelling, pain in the calf, accompanied by subcutaneous bruising. 2. Lower extremity venous return obstacle: prolonged sitting and standing or varicose veins in the lower extremities can lead to poor blood return in the lower extremities, thus causing swelling of the inner calf. 3. Kidney dysfunction: Kidneys are the main organs to excrete water in the body, when kidney dysfunction such as chronic nephritis, it will lead to edema in the calves, ankles, insteps and other parts of the body. There are many other causes of swelling of the inner calf, and it is recommended that patients consult the hospital in a timely manner to clarify the cause of the disease and standardize the treatment to avoid delaying the condition.