I. Diagnostic criteria 1. History of contact History of non-marital sexual contact, spousal infection or indirect infection. 2, bed manifestation 2,1, male and female in the genital, perineal or perianal, occasionally seen in the mouth, breast and other places appear multiple pink, gray-white or gray-brown papules or papillae, coronary or cauliflower-shaped elevated superfluous organisms. A few of them are papilloma-like proliferating giant condyloma acuminata, i.e. Buschke-Loewenstein giant condyloma acuminata. The first hospital of Zhengzhou University dermatological venereal disease Zhang Jiangan 2.2, symptoms Conscious itching, foreign body feeling, pressure or pain, often bleeding due to increased brittleness of the lesions. Women may have increased leucorrhea. 2.3, women with condyloma acuminatum should be distinguished from pseudomonal warts (villiiform labia minora), and men should be distinguished from pearl-like penile papules. The male and female should also be distinguished from flat warts, Bowen-like papillomatosis, genital sweat tuberculosis, etc. 2.4. Apply 5% acetic acid solution to the lesion and it will turn white after 3 to 5 minutes. 3, laboratory tests 3.1, skin lesion biopsy There are characteristic histopathological changes characteristic of concave hollow cells of HPV infection. 3.2, if necessary, in the skin lesion biopsy with antigen or nucleic acid test showing the presence of HPV. commonly HPV types 6 and 11, and rarely HPV types 16 and 18. 4. Classification of cases 4.1. Reported cases with indicators 1.1 and 1.2 4.2. Confirmed cases with any of the indicators 1.1, 1.2 and 1.3. II. Treatment principles 1. 1.1. Pay attention to whether the patient has gonococcal, chlamydial, mycoplasma, trichomonas, mycobacterial and other pathogenic infections at the same time, if so, they should be treated at the same time. 1.2, the patient’s spouse and sexual partner if there are condyloma acuminata or other STDs, should be treated at the same time. 1.3. Avoid sexual intercourse during the treatment period. The prognosis is generally good, but the recurrence rate is high. The first time a patient is diagnosed with a condyloma, the first time it is diagnosed. Patients who have not been diagnosed in the past should be reported when they are first diagnosed. 3.2, patients with condyloma acuminata should avoid sexual intercourse or use condoms to prevent transmission to their spouses. 3.3, patients should be treated early. 3.4, strict adherence to monogamy is the best way to prevent this disease.