With the development of modern medical imaging, endoscopic techniques have been improved and the supporting endoscopic surgical instruments have been perfected, and neuroendoscopic single nasal pterygoid sinus approach pituitary tumor resection has been successfully performed in many hospitals in China. However, there are still few reports on the resection of extra-pseudopituitary adenomas, and it is still a challenge to improve the cure rate of pituitary tumors, especially the cure rate of functional pituitary tumors. To understand extra-pseudopituitary functional pituitary adenoma resection, it is important to first understand what a pseudopituitary is. Pituitary adenomas occur in the anterior pituitary gland, the adenopituitary gland, which itself is not enveloped. The border between the adenoma and normal pituitary tissue that can be identified intraoperatively is called the pseudo-envelope, and peeling and removing the adenoma outside this border is called extraperitoneal resection. Jagannathan J et al. concluded that when adenoma tissue is removed within the pseudo-envelope, especially in large functional adenomas, postoperative hormone levels do not return to normal. This may be related to the residual adenoma cells in the pseudo-envelope. Whether endoscopic pseudoepithelial resection of pituitary adenomas causes hypopituitarism is a concern for physicians. We performed preoperative and postoperative growth hormone-releasing peptide loading tests on our patients and did not find significant hypopituitarism, which is consistent with the study by Lee EJ et al. Our experience is that pseudoepithelial adenoma resection under direct oblique endoscopy does not increase the chance of postoperative subarachnoid hemorrhage and postoperative cerebrospinal fluid leak compared to pseudoepithelial resection, except for an increased chance of intraoperative cerebrospinal fluid leak requiring abdominal fatty tissue tamponade, and instead the chance of postoperative intratumoral hemorrhage is reduced. For the treatment of prolactinoma, drugs such as bromocriptine are preferred, but the duration of taking them until cure is still not clear, and they may also be taken for a long time. Some patients cannot tolerate the side effects of drugs such as vertigo, vomiting and constipation, some patients are insensitive to drugs, the tumor does not shrink significantly after taking drugs, hormone levels do not return to normal, and some patients have the possibility of pregnancy and require surgery. 36 such patients were treated with neuroendoscopic pseudoepithelial resection of non-invasive prolactinoma through single nostril pterygoid sinus approach with high cure rate and high safety. Endoscopic pseudoepithelial resection is an alternative to pharmacological treatment for non-invasive prolactinomas. Neuroendoscopic pseudoepithelial resection of non-invasive prolactinoma via single nostril pterygoid sinus approach by experienced neuroendoscopists has high curability and safety, and is worthy of clinical promotion and application.