Most patients with leukemia develop leukemia due to malignant clonal proliferation of a particular system, so most patients in the clinic will have an increase in leukocytes i.e. total white blood cell count. There are many classifications of leukocytes, monocytes, lymphocytes, neutrophils, and may have an increased total number. In addition hemoglobin decline may crowd out many normal cells that cannot grow, so thrombocytopenia and hemoglobin decline may occur. There are also a few types of leukemia in which the white blood cells are not high and there may be some mild anemia or thrombocytopenia, which is less typical in early presentation. Some patients do not have high white blood cells, we can not let go, ignore, most of them are particularly high white blood cells, so regardless of acute and chronic leukemia, the first performance of white blood cells are particularly high, but there is no fever, infection, with infection is not good explanation. Generally fever check a blood, the blood picture is high infection. If there are no signs of infection, but the white blood cells are particularly high, we should be particularly concerned. For this leukemia that does not have high white blood cells should not be ignored and requires your attention, although it is rare, but it can also occur.