Climate change has a close relationship with the occurrence of diseases, and many diseases are characterized by a high seasonal incidence. It has long been recognized that winter is a period of high incidence of various respiratory diseases and cardiovascular and cerebrovascular diseases. In fact, due to winter lifestyle changes, the impact of cold stress or hormone replacement dose adjustment is not appropriate, so that some endocrine diseases are prone to attacks or aggravation in winter, how to do a good job of these endocrine patients in the winter protection is particularly important. Alert: Serious complications of hypothyroidism occur in winter Hypothyroidism (hypothyroidism for short) is a metabolic syndrome caused by insufficient synthesis and secretion of thyroid hormones due to various reasons. It is a metabolic syndrome caused by insufficient synthesis and secretion of thyroid hormones due to various reasons, and the ratio of male to female patients is 1:8. In recent years, the prevalence of hypothyroidism has been on the rise year by year, and according to the latest statistics, the prevalence rate of clinical hypothyroidism in our country is about 1.0%, and the total prevalence rate of subclinical hypothyroidism is as high as 6.5%. The most common cause of hypothyroidism in adults is Hashimoto’s thyroiditis, while other causes include thyroid surgery, radioiodine therapy, and insufficient iodine intake (mainly in iodine-deficient areas), etc. Hypothyroidism due to pituitary gland and hypothalamus lesions (i.e., central hypothyroidism) is relatively rare in clinical practice. The function of thyroid hormones is to regulate the development of the body and promote metabolism. Due to insufficient secretion of thyroid hormone, the basal metabolic rate of the body is lowered. Clinical manifestations of hypothyroidism include fatigue, chills, slow heartbeat, poor appetite, constipation, dry skin, hair loss, drowsiness, slow reaction time, depression, irregular menstruation, anemia, waxy complexion, and mucus oedema, etc. The body’s ability to produce heat is reduced. Due to the decreased ability of the body to produce heat, patients with hypothyroidism tend to be more afraid of cold than the general public. The dangers of hypothyroidism are systemic and related to the age of onset. Hypothyroidism in infancy often leads to short stature and mental retardation, commonly known as “cretinism”; hypothyroidism in women of childbearing age can lead to infertility, and hypothyroidism in pregnancy not only easily leads to miscarriage and preterm delivery, but also affects the intellectual development of the fetus; hypothyroidism in adults affects almost every aspect of the patient’s body, leading to abdominal distension and constipation, dyslipidemia, pericardial effusion, cardiac failure, renal failure, anemia, sexual dysfunction, depression, obesity and edema, and so on. Depression, obesity and edema, etc. The most serious complication is “mucous oedema coma”, which occurs almost exclusively in the cold winter months, and if not treated in time, the prognosis is extremely poor, with a mortality rate of up to 50%. These symptoms help hypothyroidism Winter is coming, the cold is the normal feeling of people in winter, but if a counter-intuitive extra cold, we must be careful is not “hypothyroidism” to make, of course, signs of hypothyroidism is not only afraid of the cold, when the clinical patients with the following symptoms do not forget to check the thyroid function. (1) fatigue, sleepiness, and lack of energy; (2) memory loss, delayed thinking, and difficulty in concentrating; (3) weight gain; (4) dry skin, coarsening, and brittle nails; (5) fear of cold, depressed mood, laziness, and lack of speech; (6) poorer appetite, poorer digestive function, and constipation; (7) elevated blood pressure, and a slower heartbeat; (8) generalized muscular pain, and numbness of the limbs; (9) swelling, and unexplained skin eruptions all over the body. Swelling for no apparent reason, yellowing of the skin.