Chronic hepatitis B usually requires long-term use of antiviral drugs to suppress viral replication and prevent deterioration of the disease. Chronic hepatitis B is different from hepatitis B carriers. Chronic hepatitis B usually has clinical symptoms, such as abnormal aminotransferases and abnormal liver function. At this time, the body already carries a certain amount of hepatitis B virus, and it is necessary to take long-term antiviral drugs under the guidance of doctors, such as entecavir, etc., to inhibit viral replication, and at the same time, it is also necessary to take some liver-protecting medicines to prevent further damage to liver function. Before the hepatitis B surface antigen becomes negative, chronic hepatitis B patients usually need to insist on taking medication, and cannot stop taking medication without authorization, so as to avoid the rebound of the disease. Hepatitis B surface antigen negative people, need to be under the guidance of the doctor and combined with the results of scientific stopping medication.