The diagnosis of acute osteomyelitis, like the diagnosis of general diseases, mainly depends on the patient’s medical history, clinical symptoms and imaging tests, nuclear magnetic, as well as laboratory tests. The main features of clinical symptoms are as follows: 1, the onset of the disease is relatively fast, acute, with symptoms such as high fever and coma; 2, the age of onset mainly occurs in infants, teenagers, children, etc.; 3, the main site is located in the epiphysis of long bones and adjacent joints, and the patient is reluctant to move in pain; 4, laboratory tests, the patient through the blood test, the white blood cells are relatively high to reach more than 10,000 or even 20,000, the neutrophils are relatively high, and the sedimentation rate and C-reactive protein are relatively high; 5, blood culture, through the blood culture can be cultured, the patient can be cultured by the blood culture. C-reactive protein is relatively high; 5, blood culture, through blood culture can be cultured bacteria, this time can be a clear diagnosis; 6, through modern medicine, such as magnetic resonance imaging (MRI), can be diagnosed at an early stage, the diagnosis of X-ray is relatively late, the patient may be onset of the disease after 2-3 weeks later to find out, then it will be a delay in the condition. Early magnetic resonance examination is necessary, maybe 3-5 days after the onset of the disease, the magnetic resonance examination can make a clear diagnosis. In conclusion, the diagnosis of acute hematogenous bone marrow is not difficult according to the clinical symptoms, laboratory examination, medical imaging, the main problem is early diagnosis, if the delay in diagnosis, it will cause serious complications to the patient, such as coma, bacteremia, and if caused by the destruction of bone quality will cause pain in the limbs of the patient, fracture and so on.