The first misconception: viral mutation is scary Many patients have some misconceptions about viral mutation during antiviral therapy, thinking that viral mutation is scary, but in fact viral mutation is a normal thing, any organism can mutate when it adapts to the external environment, and the mutation only accounts for a small part. As long as the patient can go to the hospital every three months for a checkup to test HBV DNA and liver function, the doctor will easily detect early viral mutations. Under the guidance of the doctor to adjust the treatment is completely able to solve the problem of viral resistance. The second misconception: new and expensive drugs are effective Some patients always use the best and most expensive drugs at the beginning of their treatment. The choice of therapeutic drugs should take into account both the condition and efficacy, as well as the cost of medicine that the patient can afford for long-term treatment. For example, entecavir has strong initial viral suppression and low mutation, but is the most expensive. For those patients who are financially well-off and can persist for at least about 3 years can consider using entecavir, and the domestic entecavir dispersible tablets are 250 yuan lower than the same drug in the joint venture, and our hospital is the preferred zero-price liver hospital in the province, which can provide greater benefit to the majority of patients. For those with poor economic conditions most patients can choose lamivudine, adefovir and other antiviral drugs that have entered the national medical insurance catalog for treatment, but also better control of the virus, in case of mutation timely treatment can also achieve a better antiviral efficacy.