Age, diabetes, hyperlipidemia, high blood viscosity, and smoking are common triggers of lower extremity arterial occlusive disease, with smoking being the number one ‘killer’ and diabetes coming in second. As early as 1911, a study found a relationship between smoking and peripheral arterial disease. Studies have shown that the incidence of intermittent claudication is three times higher in smokers than in nonsmokers, that peripheral arterial disease usually occurs ten years earlier in smokers than in nonsmokers, and that quitting smoking clearly reduces the incidence of intermittent claudication. In recent years, the incidence of lower extremity atherosclerotic occlusive disease has been increasing year by year with the improvement of the overall standard of living in society and is becoming younger. This is associated with a significant rejuvenation of patients with diabetes, hypertension, and hyperlipidemia. Some studies have shown that diabetes increases the incidence of peripheral arterial disease by 3-4 times, with a higher risk if the two are present together. Hyperlipidemia, especially elevated blood LDL and cholesterol, is strongly associated with the development of atherosclerosis in multiple sites throughout the body. The rate of amputation in diabetic patients is 5-10 times higher than that of non-diabetic peripheral artery disease, so it is important to control blood glucose, use medication under medical supervision, do not stop medication without authorization, and control diet and exercise in moderation. Numbness, pallor, soreness, weakness, dyskinesia, intermittent claudication, resting pain and even blackened toe ulcers are common symptoms of lower extremity atherosclerosis-occlusive disease, and it is recommended to go to the hospital in a timely manner, otherwise ‘the accumulation is difficult to return’ and the treatment effect will be greatly reduced. If diagnosed with lower extremity atherosclerosis occlusive disease, a carotid ultrasound is recommended for early detection of coronary artery atherosclerosis. It has been clinically found that about 26%-50% of patients with intermittent claudication of the arteries in the lower extremities have lesions in the carotid arteries when they have an ultrasound examination. Early detection and management of carotid artery stenosis can prevent and reduce the incidence of strokes.