Long-term consumption of adefovir is harmful to the body in that it may lead to adverse reactions such as renal impairment, in addition to other adverse reactions such as headache, abdominal pain, and elevated aminotransferases with adefovir. Adefovir is a nucleotide analog, belongs to the antiviral drugs, can be used for the treatment of chronic hepatitis B. For patients with renal dysfunction or potential risk of renal dysfunction, long-term intake of adefovir may lead to the manifestation of nephrotoxicity, such as abnormal urinary protein, creatinine elevation, and long-term intake can also lead to adverse reactions such as lactic acidosis, severe hepatomegaly with steatosis, and so on. When adefovir tablets cause renal tubular injury, the renal tubular breakdown of phosphorus as well as metabolism is reduced, and urinary phosphorus excretion is increased, which can lead to a decrease in blood phosphorus, and long-term hypophosphatemia may lead to an increase in phosphocreatine kinase, and the emergence of osteoporosis or hypophosphatemic osteopathy, which manifests itself as bone pain, muscle pain, and in severe cases, may lead to difficulty in walking. Adverse effects such as headache, fatigue, abdominal pain, diarrhea, nausea, flatulence, dyspepsia, leukopenia, alopecia, and reversible aminotransferase elevations can occur with adefovir, and these adverse effects usually recover after discontinuation of the drug. If you need to use adefovir, please under the supervision of a physician.