Adrenal glucocorticoids (hormones for short) have excellent immunomodulatory and anti-inflammatory effects and have been widely used clinically in the treatment of myasthenia gravis (MG), multiple sclerosis (MS) and other autoimmune and inflammatory diseases. However, various side effects can occur with hormones whether they are administered orally, intramuscularly, intravenously or topically. Moreover, the higher the dosage and the longer the duration of treatment with the drug, the more chances of side effects and the more severe the symptoms. The common side effects of long-term application of hormones are as follows: 1. Similar to adrenal glucocorticoid hyperfunction: manifested as full-moon face, buffalo back, centripetal obesity, hirsutism, acne-like rash, weakness of limbs, low blood potassium, urine sugar and other symptoms. Generally, the above symptoms can be gradually restored after stopping the drug. But the obvious symptoms should be necessary and timely treatment. 2.Infection: Long-term use of corticosteroids can reduce the body’s ability to resist disease, increasing the chance of bacterial and fungal infection, and can make the original tuberculosis lesions active and spread. 3, induce or aggravate ulcers: hormones can stimulate gastric acid secretion, reduce mucus secretion and lower gastric mucosal resistance, which can induce gastric ulcers or aggravate the condition, and even cause serious complications such as acute gastric bleeding or perforation. 4.Osteoporosis: Long-term hormone treatment can increase the excretion of calcium, inhibit the effect of vitamin D and reduce the absorption of calcium in the intestine, which can easily lead to osteoporosis and spontaneous fracture in serious cases. 5. Psychiatric symptoms: Patients who use hormones for a long time may experience excitement, insomnia, agitation, or even mild psychiatric symptoms. 6. Cardiovascular system complications: Long-term application may cause hypertension and atherosclerosis. 7. Muscle atrophy and delayed wound healing: it is related to hormones promoting protein decomposition and inhibiting its synthesis. It can also affect growth and development. It can occasionally cause malformation to pregnant women. 8.Discontinuation reaction: In patients who apply hormones for a long time, adrenocortical insufficiency may appear when the dose is reduced too quickly or suddenly stopped. However, most patients may not show it. The time of recovery of adrenocortical function is related to the dose, duration and individual differences. 9. Rebound phenomenon: The original disease relapses or worsens when the patient is dependent on hormones or the disease is not fully controlled and the drug is suddenly stopped or reduced too quickly. It can be seen that hormone is a double-edged sword, which has both advantages and disadvantages. Therefore, it is scientific to carry out individualized treatment plans for different patients and different conditions.