Acne around the mouth, usually referred to as acne on the skin around the mouth, has not been fully clarified, and is mainly considered to be caused by factors such as heredity, excessive secretion of androgens, keratinization of follicular sebaceous gland ducts, and Propionibacterium acnes infection. 1. Heredity: Acne has a certain hereditary tendency. If parents suffer from acne, the possibility of their offspring developing acne will also increase. 2. Excessive secretion of androgens: Increased levels of androgens in the body after puberty can lead to the enlargement of sebaceous glands, increased sebum secretion, and clogging of pores with sebum and shedding of dead skin cells, resulting in the formation of acne. 3. Keratinization of follicular sebaceous gland ducts: Abnormal keratinization of follicular sebaceous gland ducts will lead to narrowing of the duct opening, and the cells and sebum shed from the follicle wall cannot be discharged in time, which may lead to facial acne. 4. Propionibacterium acnes infection: When the skin is infected by Propionibacterium acnes, it can destroy the surrounding hair follicle tissues, leading to the spread of inflammation, thus contributing to the occurrence of acne. It is recommended that patients with acne around the mouth should go to the hospital in time and receive standardized treatment under the guidance of the doctor, rather than using their own medication.