Antiviral big three positive to small two positive is better, but patients still need to closely monitor the condition, there are antiviral treatment indications can not interrupt the treatment. Usually, the major triple positive refers to the hepatitis B major triple positive, refers to the hepatitis B surface antigen, E antigen, core antibody in the hepatitis B five positive, indicates that the patient’s body virus replication is more active, and has a strong contagious, and the small two positive refers to the hepatitis B surface antigen and core antibody positive, indicates that the patient’s body virus replication is not active, but still has the contagious. If the patient’s condition has improved, it is a better situation to change from major triple positive to minor bi-positive. For patients with abnormal liver function or histological damage to the liver, even if the major triple positive is changed to small second positive, patients still need to actively cooperate with the doctor’s treatment, which can effectively inhibit viral replication, and some patients can achieve clinical cure. If patients do not pay attention to it and interrupt the treatment on their own, it may cause liver damage and may also develop into cirrhosis or even hepatocellular carcinoma, which may also affect the quality of survival and life expectancy of patients. It is recommended that patients should follow up the diagnosis under the guidance of physician if the major triple yang turns into minor double yang after antiviral treatment, and do not interrupt the treatment if it is needed to avoid adverse consequences.