Palliative care for advanced lung cancer

  For early resectable lung cancer, the most important goal of surgery is complete resection of the tumor, but 70% of patients come to the hospital with locally advanced tumors or tumors that have spread, or with comorbidities that are not suitable for surgery and cannot undergo surgery. For patients with complete surgical resection, about 60% of them will eventually develop ipsilateral thoracic or distant metastases, thus, 80-85% of lung cancer patients will need palliative care. The purpose of palliative care is to relieve symptoms, reduce complications, improve quality of life and hopefully prolong survival.  I. Palliative treatment of local symptoms of tumor 1. Tracheobronchial obstruction: caused by direct obstruction of endobronchial tumor or external pressure of tumor. For endobronchial tumor obstruction, endobronchial tumor ablation can be done by biopsy with biopsy forceps or laser coagulation method, and to prevent recurrence of tumor ablation and obstruction of bronchus again, endotracheal stenting can be used; external pressure airway obstruction endotracheal stenting combined with external irradiation can have the best effect, and simple chemotherapy or radiotherapy also has a certain effect. Tracheobronchoesophageal fistula This is a rare but very sinister complication, and once it occurs, the median survival is usually no more than two months; palliative treatment aims to prevent regurgitation of gastric contents into the airway.  2. Malignant effusion Malignant pleural fluid, which can cause severe dyspnea, chest pain and coughing in patients. Many measures such as repeated thoracentesis and aspiration, pleural adhesions or indwelling catheter drainage are effective methods.  Malignant pericardial effusion Treatment is aimed at relieving symptoms, decongesting and preventing recurrence. Treatment includes simple pericardial drainage and chemical sclerotherapy, accomplished by thoracoscopy or, more commonly, by subxiphoid pericardial windowing.  3.Superior vena cava syndrome The best way to relieve superior vena cava obstruction is percutaneous placement of a self-expanding stent, which can be combined with radiotherapy after stent placement.  4.Palliative treatment of other symptoms Hemoptysis 25-40% of lung cancer patients will have hemoptysis, usually blood in sputum, and hemoptysis is rare. Most of them can be relieved by external chest irradiation; if hemoptysis occurs, bronchial artery or even pulmonary artery embolism should be considered.  Cough is rapidly relieved with codeine, and cough due to bronchial irritation from intraluminal or extraluminal tumor compression, distal atelectasis, and pneumonia can be relieved with external chest irradiation.  Chest pain Analyze the cause of chest pain and take appropriate measures. If the chest pain is caused by pleural fluid, treatment should be directed at the pleural fluid; if the chest pain originates from invasion of the chest wall or thoracic spine external irradiation is an effective way to relieve the pain.  5. Indications for palliative pneumonectomy (1) The presence of lung abscess distal to the obstructive tumor.  (2) Severe hemoptysis.  (3) Severe pain in chest wall or back due to invasion of bone tissue of chest wall.  Palliative treatment of lung cancer metastasis 1.Brain metastasis Isolated brain metastases can be completely resected. The small number of brain metastases can be treated with stereotactic radiation therapy, and the metastases are mostly relieved by whole brain irradiation.  2.Bone metastases Radiotherapy is the standard treatment for bone metastases. For long bone fractures with expected survival of more than three months, internal fixation is the most effective way to control pain, restore function and allow patients to resume normal activities.  Surgery is a treatment option for lung cancer, but only a small percentage of patients can be operated. For most patients, the primary treatment goal is remission, which can be effectively achieved through symptom relief, psychological support and prolonged survival.