IgA Nephropathy Grade IV cannot be controlled for a lifetime. It is usually impossible to guarantee the control of any disease for a lifetime without progression, due to the large differences between individuals, there are also large differences in disease control. IgA nephropathy belongs to the pathology classification, mainly refers to the renal glomerular tunica, IgA deposition induced glomerulonephritis, belongs to the more common primary glomerulonephritis, the clinical manifestations of hematuria, according to the degree of clinicopathological damage classification, IgA nephropathy grade 4 belongs to the first level. IgA nephropathy grade 4 is one of the first grade according to the grading of clinical pathology damage. It mainly refers to the glomerular mesangial area, diffuse cell proliferation, matrix deposition, about 45% of the glomeruli will be sclerosis, which belongs to a more serious type of pathology damage, and renal failure may occur, due to the irreversibility of the renal function damage, the clinical treatment is to control the progress of the disease, basically, it’s impossible to be completely cured. It is basically impossible to cure it completely. In daily life, you need to pay attention to the regular review and follow the doctor’s instructions to improve the living habits, so as to achieve a better control effect. Patients with IgA nephropathy are recommended to consult regular hospitals and receive standardized treatment under the guidance of physicians.