Stones are the product of the combination of various anions and calcium in the body and are mainly found in the urinary and biliary systems and cause pain. They are usually treated conservatively and, if necessary, surgically, and also require attention to stone prevention. Stones, whether they occur in the biliary or urinary system, can cause obstruction and smooth muscle spasm in the ducts of these systems through stimulation. The pain that occurs is usually severe, and the use of analgesic and antispasmodic medications is the main option for conservative treatment. Urinary system stones that are not large have more options for conservative treatment, with ultrasonic lithotripsy followed by lithotripsy medications, and some biliary system stones that are predominantly cholesterol crystals can be treated with lithotripsy medications. As stones are a crystalline product of calcification, their volume or distribution will become large and widely distributed with the increase of deposition. If painful episodes are more frequent and some extremely serious infections occur, leading to a decrease in the function of these systems, surgical treatment is still required. For general surgical treatment, the current trend of treatment is to choose minimally invasive treatment methods based on various lumpectomy systems. It has the characteristics of quick recovery and less damage. Stones are prone to pain and some preventive measures are still particularly important. The pain caused by these stones can occur after physical fatigue, and attention needs to be paid to maintaining a good routine and avoiding long hours of work, labor and study in order to reduce the occurrence of pain. Diet also needs to be taken seriously. Urinary system stones need to drink more water to reduce crystallization. For biliary system stones, overly greasy and fatty foods and alcohol consumption can also stimulate pain production, so they need to be avoided as much as possible. The size and location of the stones and the functional problems of the organs caused by the stones are the main factors in the treatment of stone pain and need to be examined in time and the occurrence of this pain needs to be promptly seen by a doctor.