Gastropathy of Drugs is an adverse reaction of the stomach caused by drugs, accounting for about 1/3 of drug side effects. many oral drugs can cause gastric discomfort, but sometimes non-oral administration can also cause nausea, vomiting, loss of appetite and other gastric discomfort. The clinical manifestations of drug-related gastric disease vary depending on the type of drug used, the dose, and whether it is combined with stimulant gastric drugs, but mainly the stomach is irritated, the gastric mucosal barrier suffers different degrees of damage resulting in gastric symptoms, and in severe cases, gastric ulcers and bleeding. Drug-related acute gastritis refers to superficial erosion and bleeding of the gastric mucosa or superficial ulcers caused by taking various drugs, which do not leave a scar after healing. Common causes are non-steroidal anti-inflammatory drugs (NSAIDs for short) such as aspirin, paracetamol, pau d’arco, anti-inflammatory pain and various cold medicines containing such drugs, others are antineoplastic chemotherapy drugs, digitalis, potassium chloride, sulfonamides, iron, iodine, adrenal glucocorticoids, and also acute gastric mucosal lesions caused by bad lifestyle behaviors such as alcohol abuse. Etiology of gastric symptoms during medication: 1, drugs interfere with the synthesis of mucin in the epithelial cells of the gastric mucosa, affecting the quality and quantity of gastric mucus; inhibit the synthesis of mucosal prostaglandins, inhibit the normal proliferation of mucosal epithelial cells, renewal and granulation tissue formation, so that the gastric mucosal barrier suffers damage, renewal and granulation tissue formation, so that the gastric mucosal barrier suffers damage, repair obstacles, and cause gastric mucosal erosion and ulcer formation. 2, affect the normal secretion of gastric mucosal glands, stimulate the secretion of gastric acid and pepsin. Some drugs reduce platelets, inhibit platelet aggregation, reduce thrombinogen and cause upper gastrointestinal bleeding. 3, some drugs have stimulating and corrosive effects on the gastric mucosa, such as potassium chloride and iron salts, etc. Some drugs affect the gastrointestinal motor function and the blood and lymphatic circulation of the gastric mucosa, and damage the normal function of the stomach and intestines.