With the development of medicine, the Department of Endocrinology has formed a departmental brand with “comprehensive treatment system for diabetic foot gangrene” as its core. The amputation rate of diabetic foot gangrene in the Department of Endocrinology is controlled within 6%-8%, which is much lower than the average level of 14% in China, enabling many podiatrists to avoid amputation and achieving great social benefits, which is highly praised by patients and professionals in the field. Systematic, diverse and effective treatment methods for diabetic foot disease. The “biological (medical maggot) debridement technology” researched by the endocrine laboratory for several years has become famous among diabetic patients for its unique efficacy, and has created a new chapter in the treatment of diabetic foot gangrene in China. A new chapter! It has been reported by Yangtze Evening News, Nanjing TV, Jiangsu TV and other major media. Intraluminal interventional techniques for lower limb arteries. Including lower limb artery percutaneous balloon angioplasty (PTA), lower limb artery endovascular stenting. With the advantages of minimally invasive, simple operation, precise efficacy and repeatable operation, it is the development direction of diagnosis and treatment of vascular diseases. The operation only requires a rice-sized incision at the root of the thigh, insertion of catheter, balloon and stent into the diseased artery, completion of balloon dilation and placement of stent in the narrowed and occluded artery area, and the patient can get out of bed the next day. Lower extremity vascular stem cell transplantation technology. Stem cell technology is one of the most advanced technologies in the 21st century and is rapidly being used in clinical practice. Stem cells are cells with differentiation potential and can differentiate into various body tissue cells. Stem cells from peripheral blood or bone marrow can be transplanted into ischemic limb muscles or occluded blood vessels to differentiate and form new capillaries to improve and restore blood flow in the lower limbs, thus achieving the purpose of treating lower limb ischemia. Biological (medical maggot) debridement therapy (MDT). It is a method of using the larvae of the living silky green fly for the treatment of refractory ulcer wounds, including those of diabetic foot gangrene. The application of maggots began as early as World War II, and in 2005 the FDA certified it as the first live animal that can be used in humans. Domestic research is scarce and not yet available in the southern region except for Nanjing. The medical fly species in endocrinology are cultured in the laboratory, they feed on sterile food, reproduce for more than three generations, and are tested before they are available for clinical use. three major superiorities of MDT treatment: (1) maggots clear wounds both quickly and well, they do not eat surrounding healthy tissue, and they can access deep wounds that are difficult to reach even by surgery; (2) maggots have anti-infective effects, especially against Bacillus aeruginosa, a variety of antibiotic (2) maggots have anti-infection effects, especially against Bacillus pneumoniae, multiple antibiotic-resistant Staphylococcus aureus (MRSA), etc., which can lead to faster infection control, saving a lot of antibiotics and reducing patients’ medical costs; (3) maggots produce a variety of growth factors and promote ulcer healing.