Pediatric leukemia is a group of malignant neoplastic diseases of the hematopoietic system. Early symptoms lack specificity and mostly present as anemia symptoms such as pallor and decreased appetite, and may also present with bleeding and enlarged lymph nodes. Fever and rheumatic fever-like bone and joint pain and central nervous system damage are the first symptoms in a few children. When these symptoms appear, parents should pay attention to them and seek medical attention for routine blood tests and cerebrospinal fluid examinations. 1. Some children may also have decreased mobility, such as panic, shortness of breath, and difficulty breathing after running or jumping exercises. 2. Bleeding: manifests as easy bleeding from the nose or mouth, such as bleeding from the oral mucosa when brushing teeth. It may also manifest as bleeding spots on the skin and mucous membranes, prone to petechiae and petechiae, and in severe cases, coughing up blood or blood in the stool; 3. Lymph node enlargement: manifests as enlarged liver, spleen and lymph nodes, easily detected when the neck and inguinal lymph nodes are enlarged and accompanied by pressure pain; 4. Fever: may manifest as low fever or high fever, often without obvious regularity, and the peak of fever is not fixed throughout the day. It is also easy to show symptoms of infection, such as respiratory tract infection with cough, coughing and shortness of breath, and gastrointestinal tract infection such as abdominal pain, diarrhea, nausea and vomiting; 5. Bone and joint pain: manifested as bone and joint pain, partly accompanied by sternal pressure pain; 6. Central nervous system damage: children may show symptoms such as headache, vomiting, and even convulsions and coma.