I. Shelf life of unopened and opened growth hormone (GH)
1. Growth hormone water opened: 15 days.
2. Growth hormone powder opened: 72 hours.
3.Long-acting growth hormone aqueous agent opened: 8 weeks
4. Growth hormone aqueous, powder and long-acting stored at 2-8 degrees Celsius away from light and protected from freezing.
4. validity of growth hormone aqueous and powder: 18 months
Second, will growth hormone (GH) treatment inhibit its own secretion?
For children who cannot secrete or have insufficient secretion of growth hormone, exogenous supplementation is required; secondly, since the amount of supplementation is 0,1-0,15 IU/kg/d, which is the smallest effective dose, it will not form a negative feedback effect and inhibit its own GH secretion; 0,15-0,2 IU/kg/d will not inhibit its own GH secretion either.
Third, will GH treatment accelerate bone aging?
A: The relevant domestic and foreign literature reports that GH treatment will not accelerate bone age.
D. Will GH treatment affect the fertility of children?
A: Because GH is secreted by the normal human body itself, which is necessary for human growth and development; GH can promote ovulation in fertile women and sperm maturation in fertile men, so GH treatment will not affect fertility.
V. Will GH make children fat? How to stop the medication?
A: GH is a protein, not a glucocorticoid, and will not cause fatness; it can be stopped at any time and will not cause harm to the body.
VI. Will GH treatment cause diabetes?
A: At present, the relevant literature at home and abroad reports that GH treatment will not cause diabetes.
7. Can GH treatment be used for vaccination? Can the drug be used in the treatment of general medical diseases?
A: Because GH is secreted by the normal human body itself, it can be used for vaccination during GH treatment; GH can be used for general medical treatment.
Do I need to stop GH when treating a cold?
A: General cold treatment drugs do not affect the efficacy of GH.
Note: Glucocorticoids are GH antagonist drugs, which will affect the efficacy of GH.
9. Will the efficacy of GH be affected if the child forgets to inject GH on a certain day? Do I have to make up the missed GH injection?
A: Forgetting to inject GH once in a while for one day will not affect the efficacy, and there is no need to make up the missed amount of GH.
X. How long does it take for GH to work?
A: The efficacy of GH is evaluated in 3 months, so it is necessary to go to the hospital for a review of height, weight, A function and blood sugar after 3 months of GH treatment in order to evaluate its efficacy.
XI. How old can GH treatment be discontinued at the bone age?
A: When girls BA 14 years old, boys BA 15-16 years old, the general growth rate is less than 2cm/year, in order to reduce the economic burden of parents can stop using GH.
XII. How old is the bone age can not use GH?
A: At the first visit, when the girl is 14 years old and the boy is 15 years old, the growth rate is less than 2cm/year; at this time, the child’s growth space is very limited, so GH treatment is generally not recommended.
XIII. Can children with hepatitis B and C who are short be treated with GH?
Answer.
1, Hepatitis B and C patients are the high incidence of liver cancer, while IGF-I has the effect of promoting cell mitosis and inhibiting apoptosis, GH treatment is generally not recommended.
2. Hepatitis B and C are in active stage, which must not be treated with GH.
3.Hepatitis B and C in the stable stage with normal AST and ALT can be treated with GH under close monitoring with caution.
XIV. What are the reasons for the poor efficacy of GH therapy?
Answer.
1. adequacy of GH dose.
2. Antibody production by GH powder.
3. Low thyroid function.
4. Use of glucocorticoids.
5. Epiphyseal plate closure.
6. Inaccurate measurement.
7. Having systemic chronic diseases.
8, GH treatment is ineffective.
9, whether the resident children adhere to the GH.
15. What is subclinical hypothyroidism? What should I do if hypothyroidism (mostly GHD) occurs during GH treatment?
A: Subclinical hypothyroidism: TSH is higher than normal, but T3 and T4 are in the normal range. Solution: Treatment with thyroxine tablets (with 2ug/kg/d), thyroid function will return to normal after stopping GH should stop using thyroxine.
XVI. Elevated blood sugar during GH treatment?
A: Transient elevation of blood glucose will return to normal soon; persistent high blood glucose should be followed up in hospital.