Gallbladder stones are cholesterol stones or a mixture of cholesterol-based stones and black bile pigment stones. Gallbladder stones are associated with a variety of factors. Any factor that affects the altered cholesterol to bile acid concentration ratio and causes bile stasis can lead to stone formation. Most patients have asymptomatic gallbladder stones, which are called quiescent gallbladder stones. In a small number of patients, the typical symptom of gallbladder stones is biliary colic, which manifests as acute or chronic cholecystitis. So who is prone to gallstones? The reason is that the high level of estrogen in women’s bodies affects the formation of glucuronide bilirubin in the liver and increases unconjugated bilirubin; estrogen also affects gallbladder emptying and causes bile stagnation, which makes it very easy to form stones. The incidence of gallstones increases in postmenopausal patients with estrogen. 2, patients with cirrhosis The incidence of gallstones in patients with cirrhosis is significantly higher than in normal people, which is related to the reduced inactivation of estrogen in the body of patients with cirrhosis, higher estrogen levels, and chronic hemolysis, low gallbladder contraction, poor emptying of the gallbladder, biliary varices, and elevated bilirubin in blood. 3, overweight obese people whose body weight exceeds 15% of the normal standard, the incidence of gallstones is 5 times higher than normal people. Most obese people have excessive fat and cholesterol intake, and most obese people have less activity, which makes them prone to gallstones. 4, the diet of meat, sweet and do not eat breakfast diet meat like sweet, their fat and cholesterol intake, easy to form cholesterol stones; too much sweet food and promote insulin secretion, will accelerate cholesterol deposition; often do not eat breakfast will reduce the content of bile acid, bile concentration, conducive to stone formation. 5, people with roundworms in the body roundworm infection do not pay attention to dietary hygiene infected with roundworm disease, roundworms reflux to the biliary tract to lay eggs or die, it will become the core of stones, the formation of stones. 6.Patients with family history of hereditary disease In addition, genetic factors affect the occurrence of gallstones. Therefore, immediate family members such as parents, siblings or children with gallstones are also at high risk of occurrence. Gallstones cause a lot of inconvenience to the patient. 90% of biliary colic attacks are sudden and the pain is often located in the upper abdomen or right upper abdomen and radiates to the shoulders and back. The pain is often located in the upper abdomen or right upper abdomen and radiates to the shoulders and back. It usually occurs easily when eating very well, after overexertion or strenuous exercise; some patients may have sudden attacks at night. In addition to the symptoms of severe pain, there is often restlessness, even tossing and turning, profuse sweating, pale face and some other manifestations, nausea, vomiting, etc. may also occur. Each attack usually lasts for a period of time and often takes a long time to be relieved.