The soreness of the thighs after drinking alcohol is usually caused by the following reasons: 1, people usually enter 3 periods after drinking alcohol, namely the excitement period, ataxia period and coma and lethargy period, when they fall into the ataxia period, they are especially vulnerable to trauma, such as those caused by excessive force or stretching, stretching and straining of the thighs can cause soreness. 2, after drinking too much alcohol, the ethanol in alcohol will be quickly converted into acetaldehyde in the liver ethanol The process of alcohol metabolism will also release several substances such as acetyl and acetic acid, which are acidic metabolites that can lead to self-induced soreness in the thighs and in the more muscular areas of the body.