Kidney disease in children has become one of the diseases that seriously threaten children’s health. If children’s kidney disease is not detected early and treated timely and effectively, the progress of kidney function damage is not effectively delayed, the disease may progress, and serious cases may develop kidney failure in adolescence or adulthood to the point of needing kidney dialysis and kidney transplantation treatment, which brings a heavy burden to families. Therefore, early diagnosis and effective treatment of kidney disease in children has become a top priority. As many patients with chronic kidney disease do not show obvious symptoms at the beginning, some children with kidney disease can eat and drink and look very healthy, so parents can easily ignore their children’s kidney disease, and often come to the hospital only after the children have blood in the urine and high swelling, which will delay the disease and miss the best treatment time. Therefore, parents should pay special attention to observe their children and pay enough attention when they find the following signs of kidney disease in children: 1. Edema: Eyelid or lower limb edema may be one of the manifestations of kidney disease in children. It is mainly manifested as sunken edema starting from eyelids or ankles, which develops rapidly and is usually accompanied by a decrease in urine volume, with hematuria and proteinuria visible in auxiliary examinations. 2, too much or too little urine: normally, the urine volume is 400~600ml/day for infants, 600~800ml/day for preschoolers, and 800~1400ml/day for school-age children. Abnormal changes in urine volume may be a warning signal from the kidneys, suggesting that childhood kidney disease may have occurred. 3, careful observation of the child’s urine, if you find a lot of foam in the urine, and in the toilet to retain a long time is not easy to dissipate, this may also be a manifestation of children’s kidney disease. Once the above situation is found, for the sake of insurance, parents should immediately go to the hospital to do a routine urine test for their children, which is the most basic and easiest way to detect kidney disease in children at an early stage. If proteinuria, red blood cells, white blood cells, urine sugar, etc. are found in the routine urine examination, further examination should be done according to the doctor’s suggestion to clarify the cause of kidney disease in children. It is worth noting that schools and kindergartens tend to ignore urine tests when organizing physical examinations for children, therefore, parents must pay great attention to strengthen the supervision of their children’s health.