It can be said that the first thing to consider in pregnancy is not mother-to-child transmission but whether the mother can bear the pregnancy, because when a woman is pregnant, she needs to provide a lot of nutrition for the fetus, which increases the burden on the liver during pregnancy, and the changes in the immune function and endocrine of the body during pregnancy can lead to aggravation of the original liver disease. In addition, the immune function and endocrine changes of the body during pregnancy can lead to the aggravation of the existing liver disease and the reduction of liver function, so it is very meaningful to avoid the unsuitable time for pregnancy for the health of oneself and the fetus. Clinically, hepatitis B women should not be pregnant in five situations: 1, acute hepatitis B period and accompanied by obvious abnormal liver function; 2, chronic hepatitis B but abnormal liver function and fluctuate greatly, with or without protein ratio inversion or hypoproteinemia; 3, hepatitis B virus infection for a long time and serious liver damage, pathological examination of cirrhosis, and accompanied by significant thrombocytopenia, hypersplenism, coagulation dysfunction; 4, with serious kidney disease, heart disease, aplastic anemia, etc.; 5, with a history of pregnancy, but the pregnancy was terminated because the liver could not bear it.