Urological stones are one of the most common diseases in urology. For large and complex stones, the only treatment is surgery, but large incisions and open surgery are difficult for most patients to accept. Minimally invasive treatment of stones is an emerging advanced surgical procedure. Over the past decade, minimally invasive techniques have been carried out quite extensively in the treatment of lower and middle ureteral stones, bladder stones, and urethral stones at our hospital, with numerous recoveries. In the past two years, we have continued to develop the minimally invasive technique for kidney stones – percutaneous nephrolithotomy with ultrasound combined with ballistic lithotripsy, which has led to another rapid development of minimally invasive techniques. At present, we have been able to complete the simultaneous minimally invasive treatment of huge stones in both kidneys of the same patient, with the largest stone reaching 5.6×4.0M2, with patients from Zhanjiang in the near future and patients from Guangxi and Hunan in the far future. The oldest patient was 78 years old and the youngest was 24 years old. This procedure is mainly for calcium stones, pelvic stones, upper ureteral stones, antler-shaped kidney stones, residual or recurrent stones after open surgery, and hydronephrosis, especially in the antler-shaped kidney stones which are difficult to be treated by open surgery. The specific operation is: under the positioning of ultrasound and X-ray machine, a stoma tube is punctured into the renal pelvis and calyces through the patient’s lumbar region, and subsequently dilated to the channel of F14 – F20 segment (single channel or multiple channels are possible). The stone is then crushed and removed from the body at high speed using ultrasound combined with ballistic lithotripsy. It is worth mentioning that this ultrasonic lithotripsy system is the most advanced lithotripsy equipment in China. The advantages of this procedure are: ① Minimally invasive. Minimal orifice incision, pain is reduced to the minimum, patients can eat on the same day after surgery, less trauma and bleeding during surgery, and blood transfusion is generally not required, and none of our patients need blood transfusion at present. ②The surgery can be performed in stages and is easily tolerated by patients. ③Low surgical risk. Compared with open surgery, complications such as heavy bleeding and retention of residual stones are reduced. ④Fast recovery and can be discharged from the hospital in 4 – 5 days after surgery.